421 Broadway, Residence 6 - A Rare and Iconic SoHo Loft Opportunity A true SoHo original, Residence 6 at 421 Broadway offers the kind of scale, light, and character that is increasingly rare in SoHo. Spanning over 5,200 square feet across two levels, this full-floor duplex loft captures the essence of classic SoHo living - generous proportions, abundant natural light from multiple skylights and windows on all sides, and a layout designed for both grand entertaining and everyday life. The residence offers five bedrooms and three bathrooms, with a formal dining room that opens directly into a generous living and entertaining space, creating an ideal flow for hosting and gathering. Multiple distinct living areas across both levels provide flexibility, separation, and the ability to entertain with ease, while skylights bring natural light deep into the home throughout the day. Two wood-burning fireplaces add warmth and character. The home also offers multiple opportunities for entertaining, including two private terraces - highly coveted amenities in SoHo and a natural extension of the loft lifestyle. Rich in history and creative legacy, this apartment once stood at the heart of the downtown art world, serving as a gathering place for artists, dealers, and collectors who helped shape a generation of contemporary art. It was also associated with the early presentation of artists such as Jean-Michel Basquiat, Keith Haring, Jeff Koons, and Julian Schnabel. Rooted in SoHo's artistic legacy and architectural history, this is a rare opportunity to shape and refine a residence of lasting significance in one of Manhattan's most iconic neighborhoods. Opportunities offering this combination of scale, light, flexibility, and cultural pedigree are increasingly uncommon. Residence 6 is defined not by finishes, but by space, history, and possibility - an authentic SoHo loft ready for its next chapter.